Several
studies combining together with BK polyomavirus and prostate cancer suggested
that this virus may utilize its oncogenic activity at the early stages of
cancer development. The BK polyomavirus oncogene, the large T antigen, has periodically
been observed in areas of proliferative inflammatory atrophy, which is
considered a precursor lesion leading to prostatic intraepithelial neoplasia
and overt prostate cancer. In a recently updated systematic review, the
presence of BK polyomavirus was symbolically higher in prostate cancer tissues
than in healthy control tissues, providing an indication for a link between BK
polyomavirus infection and cancer risk. In addition to this, the recent
original investigations highlighted an association between expression of the
virus and the clinical course of prostate cancer. Although a complete picture
of the mechanisms potentially responsible for the involvement of BK
polyomavirus in prostate cancer is not yet available.
Click here to view the journal: Clinical and ExperimentalGenetics
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